James Holehouse Stochasticity and Complexity

Research

I’m James, a postdoc at the Santa Fe Institute! I completed my PhD in Mathematical Biology at the University of Edinburgh. I obtained a first-class honors degree in Theoretical Physics (MPhys) from the University of Edinburgh. My main interests span several aspects of complexity science and statistical physics:

  • Stochasticity and its non-intuitive consequences.
  • The effects of randomness on gene expression.
  • Rules and regulations across different complex systems.

Examples of these interests include work on time-dependent solutions of master equations in mathematical biology and social choice, explorations of transient modalities in stochastic processes that are not due to competing modes of behavior, and recent work on the evolution of rules and regulations in documents such as the US Code or in sports.

All my publications are either open-science or else can be accessed on the arXiv or bioarXiv (or send me an email and I’ll send you the article). You can access my full CV here, and a video lay summary of some of my research here (made by the talented Pedro Marquez-Zacarias). Please get in touch—I’m always free for discussion of cool topics!

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Featured Publications

Holehouse, J. (2024). Pre-print. Principles of bursty mRNA expression and irreversibility in single cells and extrinsically varying populations. arXiv preprint arXiv:2405.12897

Holehouse, J., & Redner, S. (2024). First-passage on disordered intervals. Physical Review E, 109(3), L032102.

Holehouse, J. (2024). Thesis summary: Model reduction, mechanistic modelling and transience in models of stochastic chemical kinetics. European Communications in Mathematical and Theoretical Biology Volume 26 (2023), p. 6-14

Wu, B., Holehouse, J., Grima, R., & Jia, C. (2024). Solving the time-dependent protein distributions for autoregulated bursty gene expression using spectral decomposition. The Journal of Chemical Physics, 160(7)

Weidemann, D. E., Holehouse, J., Singh, A., Grima, R., & Hauf, S. (2023). The minimal intrinsic stochasticity of constitutively expressed eukaryotic genes is sub-Poissonian. Science Advances, 9(32), eadh5138.

Holehouse, J. (2023). Holehouse, James. Recurrence and Eigenfunction Methods for Non-Trivial Models of Discrete Binary Choice. Entropy.

Updates

Talk on Ruin Problems at the London Mathematical Labratory's Ergodicity Economics seminar series - November 8, 2024

Curating Sports Rule Books in Rugby and Cricket - September 8, 2024

Talk at the Complex Systems Society conference in Exeter - September 6, 2024

Plenary talk and contributed talk at ECMTB 2024 - July 25, 2024

IC2S2 presentation on diversity and specialization across social and biological systems - July 18, 2024

Talk at lab of Prof. Hernan Garcia at UC Berkeley - June 10, 2024

Talk and seminar series at St. Johns College, Santa Fe - May 8, 2024

Paper published as a letter in PRE on first-passage on disordered intervals - March 7, 2024

Awarded the Reinhart Heinrich Award for best thesis in Mathematical Biology from ESMTB - July 4, 2023

PhD awarded for thesis "Model reduction, mechanistic modelling and transience in models of stochastic chemical kinetics" - October 12, 2022

New Publication on Time-Dependent Solutions to Kirman's Ants - September 7, 2022