James Holehouse Quantitative Biology and Complexity

Research

I’m James, a postdoc at the Santa Fe Institute. I completed my PhD in Mathematical Biology, supervised by Prof. Ramon Grima at the University of Edinburgh. Much of my research has centred on stochastic gene expression, although I have also engaged with topics as diverse as enzyme kinetics, social choice models and cross situational learning.

In my postdoc I will look to explain scaling behaviours in regulatory networks. I am also still engaged in projects on analytics and inference in models of stochastic gene expression. All my publications are either open-science or else can be accessed on the arXiv or bioarXiv (or send me an email and I’ll send you the article). Feel free contact me at jamesholehouse1@gmail.com, I’m always free for discussion and collaboration. You can access my full CV here.

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Publications

Holehouse, J., & Redner, S. (2023). First-passage on disordered intervals. arXiv preprint arXiv:2307.08879.

Weidemann, D. E., Holehouse, J., Singh, A., Grima, R., & Hauf, S. (2023). The minimal intrinsic stochasticity of constitutively expressed eukaryotic genes is sub-Poissonian. Science Advances, 9(32), eadh5138.

Holehouse, J. (2023). Holehouse, James. Recurrence and Eigenfunction Methods for Non-Trivial Models of Discrete Binary Choice. Entropy.

Holehouse, J., & Moran, J. (2022). Exact time-dependent dynamics of discrete binary choice models. Journal of Physics: Complexity.

Holehouse, J., & Pollitt, H. (2022). Non-equilibrium time-dependent solution to discrete choice with social interactions. PLoS ONE.

Braichenko, S., Holehouse, J., & Grima, R. (2021). Distinguishing between models of mammalian gene expression: telegraph-like models versus mechanistic models. J. R. Soc. Interface.

Holehouse, J., Sukys, A., & Grima, R. (2020). Stochastic time-dependent enzyme kinetics: Closed-form solution and transient bimodality. The Journal of Chemical Physics.

Holehouse, J., Gupta, A., & Grima, R. (2020). Steady-state fluctuations of a genetic feedback loop with fluctuating rate parameters using the unified colored noise approximation. Journal of Physics A: Mathematical and Theoretical.

Holehouse, J., Cao, Z., & Grima, R. (2020). Stochastic modeling of autoregulatory genetic feedback loops: A review and comparative study. Biophysical Journal.

Holehouse, J., & Grima, R. (2019). Revisiting the reduction of stochastic models of genetic feedback loops with fast promoter switching. Biophysical Journal.

Updates

Awarded the Reinhart Heinrich Award from ESMTB - July 4, 2023

PhD awarded for thesis "Model reduction, mechanistic modelling and transience in models of stochastic chemical kinetics" - October 12, 2022

New Publication on Time-Dependent Solutions to Kirman's Ants - September 7, 2022