James Holehouse Quantitative Biology and Complexity

Research

I’m James, a postdoc researcher at the Santa Fe Institute. I completed my PhD in Mathematical Biology, supervised by Prof. Ramon Grima. Much of my research has centred on stochastic gene expression, although I have also engaged with topics as diverse as enzyme kinetics, social choice models and cross situational learning.

Currently in my postdoc I will look to explain scaling behaviours in regulatory networks. I am also still engaged in projects on analytics and inference in models of stochastic gene expression. All my publications are either open-science or else can be accessed on the arXiv or bioarXiv (or send me an email and I’ll send you the article). Feel free contact me at jamesholehouse1@gmail.com, I’m always free for discussion and collaboration. You can access my full CV here.

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Publications

Holehouse, J. (2023). Pre-print. Closed-form solution of a general three-term recurrence relation: applications to Heun functions and social choice models

Holehouse, J., & Moran, J. (2022). Exact time-dependent dynamics of discrete binary choice models. Journal of Physics: Complexity.

Holehouse, J., & Pollitt, H. (2022). Non-equilibrium time-dependent solution to discrete choice with social interactions. PLoS ONE.

Braichenko, S., Holehouse, J., & Grima, R. (2021). Distinguishing between models of mammalian gene expression: telegraph-like models versus mechanistic models. J. R. Soc. Interface.

Holehouse, J., Sukys, A., & Grima, R. (2020). Stochastic time-dependent enzyme kinetics: Closed-form solution and transient bimodality. The Journal of Chemical Physics.

Holehouse, J., Gupta, A., & Grima, R. (2020). Steady-state fluctuations of a genetic feedback loop with fluctuating rate parameters using the unified colored noise approximation. Journal of Physics A: Mathematical and Theoretical.

Holehouse, J., Cao, Z., & Grima, R. (2020). Stochastic modeling of autoregulatory genetic feedback loops: A review and comparative study. Biophysical Journal.

Holehouse, J., & Grima, R. (2019). Revisiting the reduction of stochastic models of genetic feedback loops with fast promoter switching. Biophysical Journal.

Updates

PhD awarded for thesis "Model reduction, mechanistic modelling and transience in models of stochastic chemical kinetics" - October 12, 2022

New Publication on Time-Dependent Solutions to Kirman's Ants - September 7, 2022